Roger Greenberg, a quirky and neurotic man, returns to Los Angeles to house-sit for his brother. As he navigates through his mid-life crisis, he forms an unexpected bond with his brother's assistant, Florence, who is trying to figure out her own life. Their unique connection challenges Greenberg to confront his past and reassess his future. Amidst the backdrop of LA's bustling cityscape, the two characters embark on a journey of self-discovery, love, and second chances. "Greenberg" is a heartfelt and humorous tale of finding oneself in the midst of life's uncertainties.